The scientist rewriting DNA, and the future of medicine
David Liu, a molecular biologist at the Broad Institute of Harvard and MIT, has won the 2025 Breakthrough Prize for inventing two cutting-edge gene editing tools: base editing and prime editing. Base editing corrects single DNA-letter mutations and is already used in clinical trials, while prime editing can rewrite entire DNA segments—like a “find and replace” function. These tools hold the potential to cure genetic diseases such as leukemia, cystic fibrosis, and sickle cell. Liu warns, however, that U.S. science funding cuts threaten future progress, likening them to “burning your seed corn.”
重写DNA的科学家和医学的未来
哈佛大学和麻省学院布罗德研究所分子生物学家大卫刘因发明双重尖端基因编辑工具而获得2025年突破奖：碱基编辑和主要编辑。碱基编辑可以修复单个DNA突变，并已用于临床试验，而主要编辑重写整个DNA片段——就像“创新和替换”功能一样。这些工具有可能治愈白化、囊性纤维化和镰状细胞状等遗传。然而，刘警告说，美国科学已经威胁到未来的进步，将其比作“掉你的种子玉米”。
Alberto Ascherio receives Breakthrough Prize for groundbreaking research on multiple sclerosis
Harvard epidemiologist Alberto Ascherio received the 2025 Breakthrough Prize in Life Sciences for research proving that Epstein-Barr virus (EBV) is the leading cause of multiple sclerosis (MS). His landmark 2022 Science study, using 20 years of U.S. military data, showed a 32-fold increased MS risk after EBV infection. The discovery has spurred vaccine and treatment development. Ascherio, known for his long-term vision and global public health background, continues investigating viral links to neurodegenerative diseases and calls for funding to unlock breakthroughs, including for Alzheimer’s disease.
阿尔贝托·阿切里奥因多发性症的开创性研究突破奖
哈佛大学流行病学家阿尔贝托Ascherio因运算爱泼斯坦-巴尔病毒（EBV）是多发性乳腺癌（MS）的主要研究并获得2025年生命科学突破奖。他的里程碑式2022年科学研究利用了20年的美国军事数据，表明EBV感染随后MS风险增加了32倍。这一发现促进了疫苗和治疗方法的开发。阿切里奥在疫情持续扩散和全球公共卫生背景下而闻名，他继续研究病毒与神经退行的联系，并呼吁提供资金以取得突破，包括阿尔茨海默病。
New York Times: With Universities Threatened, Can Boston Still Be Boston?
Boston’s identity as a global academic hub is under threat as the Trump administration slashes federal funding for universities and hospitals. Harvard faces a $9 billion review, labs are closing, international students are being deported, and offers to Ph.D. students have been rescinded. Massachusetts—top in per capita research funding—is leading lawsuits, while city leaders like Mayor Michelle Wu warn of long-term damage to the economy, science, and global competitiveness. Amid uncertainty, researchers fear brain drain, and Boston's historic foundation in education and innovation faces a profound reckoning.
纽约时报：大学受到威胁，波士顿还能是波士顿吗？
随着特朗普政府大幅削减对大学和医院的资助，波士顿作为全球学术中心的地位正受到威胁。90亿美元的审查，实验室正在关闭，国际学生被驱逐出境，博士生的录取通知也被取消。马萨诸塞州是人均研究最严重的州，正在带头提起诉讼，而领导人吴小晖等城市领导人警告称，这可能对经济、科学和全球贸易造成长期危害。在不确定性中，研究人员担心人才流失，波士顿在教育和创新方面的历史基础正在着眼于未来。
'Highly narcissistic' people love to say these 7 phrases—here's how to respond: Harvard-trained psychologist
Harvard-trained psychologist Dr. Cortney S. Warren identifies 7 common phrases used by highly narcissistic people, including “You’re lucky I even care” and “My feelings are your fault”, which reflect their manipulation, lack of empathy, and need for control. She advises not to react emotionally but instead pause, set firm boundaries, and recognize that their toxic words reflect their own inner struggles—not your worth. Warren emphasizes that staying calm and grounded is the best defense against narcissistic communication.
“高度自恋”的人喜欢说这7句话——以下是如何回应的：哈佛移植
哈佛大学法官科特尼·沃伦博士，高度指出自恋的人会说7个常用的，“你很幸运，我担心你”和“我的感觉是你的错”，建议不要情绪化地做出反应，而是停下来，设定闹钟的界限，并认识到自己的言语，反映自己的内心困境，而不是你的价值。沃伦强调、包括和保持关注的方法是理解他们自恋沟通的最好方法。
Harvard nutritionist eats these 5 foods to keep her 'immune system strong' and 'energy high'
Dr. Uma Naidoo, a Harvard-trained nutritional psychiatrist, shares the 5 key foods she relies on to keep her immune system strong and energy high during winter:
- Citrus fruits for vitamin C and gut-friendly fiber,
- Leafy greens for folate and microbiome balance,
- Clean proteins like tofu and salmon for mood-boosting B vitamins,
- Fermented foods to support gut health, and
- Warming spices (turmeric, ginger, etc.) for their anti-inflammatory benefits.
She emphasizes gut health as central to both immunity and mental well-being.
哈佛营养师吃这5种食物来保持“免疫系统增强”和“精力充沛”
哈佛大学的营养精神病学家乌玛·奈杜(Uma Naidoo)博士分享了她在冬季保持免疫系统强大和精力充沛所依赖的5种关键食物：
- 柑橘类水果含有维生素C和增强破坏的纤维，
- 绿叶蔬菜有助于叶酸和维生素群的平衡，
- 豆腐和鲑鱼等清洁蛋白质可提供改善情绪的B族维生素，
- 发酵食品有利于破坏健康，
- 温热香料（姜黄、生姜等）具有抗炎功效。
她强调增强健康对强化和心理健康至关重要。
哈佛大学40年凝练！校长亲自作序，两位诺奖得主联袂力荐的思维准则！
《分析思维的准则》是哈佛大学教授理查德·泽克豪泽40年教学与研究的智慧结晶，由其弟子丹·利维整理成书，荣获两位诺贝尔经济学奖得主与哈佛荣誉校长联袂推荐。这本书凝练出19条思维准则，帮助读者在不确定性中做出理性判断、优化决策路径，被誉为“哈佛最实用的思维课”。无论在政策分析、投资判断还是日常生活中，它都是破解复杂世界的分析工具书，在AI时代尤显珍贵。
哈佛专家比拼8大饮食法，这样吃活到75岁机率高2倍
哈佛大学联合多国研究团队，追踪超过10万人30年健康数据，评估8种饮食模式对“健康老龄化”的影响。结果显示，最能延长健康寿命的是“替代健康饮食指数（AHEI）”，其坚持度最高者在75岁时健康老龄化概率高出2.24倍。该饮食强调多摄入蔬果、坚果、全谷物、不饱和脂肪，避免红肉、含糖饮品、反式脂肪和钠。研究还指出，超加工食品会降低健康老化机会达32%，并强调饮食应因人而异，灵活调整更关键。
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